Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization

Plants are rich in secondary metabolites, which often useful as a relevant source of nutraceuticals. Quercetin (QUE) is flavonol aglycone able to bind Transthyretin (TTR), plasma protein that under pathological conditions can lose its native structure leading fibrils formation and amyloid diseases onset. Here, the dual nature five quercetin 3-O-glycosylated derivatives, isolated from different plant species, such possible binders TTR antioxidants, was investigated. The crystal 3-O-?-D-galactopyranoside complex with solved, suggesting not only but also metabolites contribute stabilizing tetramer.